Publications by authors named "Eleonora Zenobi"

Exposure to high levels of radiation can cause acute, long-term health effects, such as acute radiation syndrome, cancer, and cardiovascular disease. This is an important occupational hazard in different fields, such as the aerospace and healthcare industry, as well as a crucial burden to overcome to boost space applications and exploration. Protective bulky equipment made of heavy metals is not suitable for many advanced purporses, such as mobile devices, wearable shields, and manned spacecrafts.

View Article and Find Full Text PDF
Article Synopsis
  • Human mesenchymal stem cells (hMSCs) respond to mechanical and biophysical signals, with pulsed electromagnetic field (PEMF) stimulation showing promise in treating musculoskeletal disorders and enhancing bone tissue engineering.
  • This study examines the effects of PEMF on bone regeneration by creating trabecular bone-like tissues, culturing them in a bioreactor, and analyzing cellular signaling pathways through transcriptomic studies.
  • Results indicate that PEMF boosts hMSC immune responses and stimulates processes like angiogenesis and osteogenesis, reflecting key aspects of bone healing, showcasing the potential of the bioreactor platform for future research.
View Article and Find Full Text PDF

Intrinsic permeability describes the ability of a porous medium to be penetrated by a fluid. Considering porous scaffolds for tissue engineering (TE) applications, this macroscopic variable can strongly influence the transport of oxygen and nutrients, the cell seeding process, and the transmission of fluid forces to the cells, playing a crucial role in determining scaffold efficacy. Thus, accurately measuring the permeability of porous scaffolds could represent an essential step in their optimization process.

View Article and Find Full Text PDF

Material extrusion (MEX), commonly referred to as fused deposition modeling (FDM) or fused filament fabrication (FFF), is a versatile and cost-effective technique to fabricate suitable scaffolds for tissue engineering. Driven by a computer-aided design input, specific patterns can be easily collected in an extremely reproducible and repeatable process. Referring to possible skeletal affections, 3D-printed scaffolds can support tissue regeneration of large bone defects with complex geometries, an open major clinical challenge.

View Article and Find Full Text PDF