The role of high molecular weight hyaluronic acid in mucoadhesion on an ocular surface model.

Hyaluronic acid (HA) is frequently formulated in eye drops to improve the stability of the tear film by hydration and lubrication. Mucoadhesion is related to the ocular residence time and therefore to the effectiveness of the eye drops. The ocular residence time of the HA formulation is correlated with the ability of HA to create specific strong interactions in the ocular surface with the mucus layer, mainly composed of a mixture of secreted mucins (MUC; gel forming MUC5AC and MUC2) and shed membrane-bound soluble mucins (MUC1, MUC4, and MUC16).

Typing and Molecular Characterization of Antimicrobial Resistance in Strains from Patients with Cystic Fibrosis.

We characterized strains isolated from cystic fibrosis (CF) patients during screening for multidrug-resistant strains to determine mechanisms of antibiotic resistance and conduct typing. We investigated 53 isolates collected from different CF patients, excluding multiple isolates from the same patient. Genotypic characterization was based on type (protein A); staphylococcal cassette chromosome () type for resistant to methicillin (methicillin-resistant [MRSA]); and resistance to the most common macrolides, lincosamides, and streptogramins b and fluoroquinolones.