Synopsis of recent research by authors named "Eleonora Panfili"
- Eleonora Panfili's recent research primarily focuses on the role of indoleamine 2,3-dioxygenase 1 (IDO1) in immunoregulation and its implications in cancer therapy, highlighting both its enzymatic and non-enzymatic functions that contribute to tumor immune escape and immune responses in various pathological settings.
- Several studies by Panfili investigate novel inhibitors of IDO1, such as epacadostat, and their potential to modulate IDO1's signaling pathways, revealing insights into the protein’s dual role in contributing to a tolerogenic immune environment and its impact on tumor microenvironments and autoimmune diseases.
- Additionally, her work explores the immunomodulatory effects of small nucleic acid-based compounds derived from HIV-1, the influence of Toll-like receptors in autoimmune disease pathogenesis, and the metabolic implications of amino acids in conditions like diabetes and rheumatoid arthritis, indicating a broad interest in the intersection of metabolism and immune regulation.*
