Detection of the bla(VIM-12) gene within the originally described Inh12 integron in a clinical isolate of Enterobacter cloacae is reported for the first time worldwide. Integron Inh12 was carried on a conjugative plasmid of approximately 85 kb which also conferred resistance to aztreonam, likely due to AmpC production.
View Article and Find Full Text PDFObjective: To assess outcomes with de-escalation therapy in ventilator-associated pneumonia (VAP).
Design: Prospective observational study.
Setting: Multidisciplinary intensive care unit.
Objective: To compare the causative pathogens of early-onset and late-onset ventilator-associated pneumonia (VAP) diagnosed by bronchoalveolar lavage quantitative cultures. Most previous reports have been based on endotracheal aspirate cultures and gave uncertain findings.
Design: Prospective evaluation of consecutive patients with clinical suspicion for VAP.