Publications by authors named "Eleni Mijalis"
Background: Rural pediatric firearm injuries require regional pediatric and trauma expertise. We evaluated county-level population density associations with transport, hospital interventions, and patient outcomes at a Level I pediatric trauma center serving a rural, statewide catchment area.
Material And Methods: The trauma registry of the only in-state pediatric trauma center was reviewed for firearm injuries in patients < 18 between 1/2013 and 3/2020.
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remains common, and severe complications are associated with ERCP. There is no previous study detailing the effect of race and gender in a US-based population on risk of PEP.
Methods: Data were collected on 269 "first-performed" consecutive ERCPs followed by division by race (White vs.
An 86-year-old woman was referred to the otolaryngology clinic for a 1-year history of a painless, slow-growing neck mass. Physical examination showed a fixed, immobile right level II neck mass with normal vocal cord movement. MRI demonstrated a lobulated mass laterally displacing the carotid vessels, consistent with a schwannoma.
View Article and Find Full Text PDFIn the modern genomic era, scientists without extensive bioinformatic training need to apply high-power computational analyses to critical tasks like phage genome annotation. At the Center for Phage Technology (CPT), we developed a suite of phage-oriented tools housed in open, user-friendly web-based interfaces. A Galaxy platform conducts computationally intensive analyses and Apollo, a collaborative genome annotation editor, visualizes the results of these analyses.
View Article and Find Full Text PDFPhage spanins: diversity, topological dynamics and gene convergence.
BMC Bioinformatics
September 2018
Article Synopsis
- Spanins are essential phage lysis proteins that facilitate the breakdown of the outer membrane in Gram-negative bacteria, existing as either two-component spanins (like Rz-Rz1) or unimolecular spanins (like gp11), each with distinct structural features and functions.* -
- The study introduces the SpaninDataBase, which catalogs 528 two-component spanins and 58 unimolecular spanins, revealing significant differences in their secondary structures and highlighting the vast diversity among spanin families through genetic analysis.* -
- Findings suggest that, despite their structural differences, both types of spanins share a common mechanism that involves the fusion of the outer and inner membranes to release viral progeny, while also showing evolutionary insights
is responsible for various opportunistic nosocomial infections. Phage therapies against may prove useful in human medicine for treatment of infections caused by the ubiquitous bacteria. Here, we announce the complete genome sequence of the Felix O1-like myophage Mijalis and present its features.
View Article and Find Full Text PDFKlebsiella pneumoniae is a Gram-negative pathogen frequently associated with antibiotic-resistant nosocomial infections. Bacteriophage therapy against K. pneumoniae may be possible to combat these infections.
View Article and Find Full Text PDFAims/hypothesis: We had previously reported that stromal cell-derived factor 1 (SDF-1) mediates chemorepulsion of diabetogenic T cell adhesion to islet microvascular endothelium through unknown mechanisms in NOD mice. Here we report that SDF-1-mediated chemorepulsion occurs through slit homologue (SLIT)2-roundabout, axon guidance receptor, homologue 1 (Drosophila) (ROBO1) interactions.
Methods: C-X-C receptor (CXCR)4 and ROBO1 protein expression was measured in mouse and human T cells.