Serum Concentrations and Dietary Intake of Vitamin B in Children and Adolescents on Metformin: A Case-Control Study.

The International Society of Pediatric and Adolescent Diabetes (ISPAD) recommends metformin (MET) use for metabolic disturbances and hyperglycemia, either in combination with insulin therapy or alone. A caveat of MET therapy has been suggested to be biochemical vitamin B deficiency, as seen mainly in studies conducted in adults. In the present case-control study, children and adolescents of different weight status tiers on MET therapy for a median of 17 months formed the cases group ( = 23) and were compared with their peers not taking MET ( = 46).