Publications by authors named "Eleni Anagnostopoulou"
Gemcitabine (2',2'-difluoro-2'-deoxycytidine), a widely used anticancer drug, is considered a gold standard in treating aggressive pancreatic cancers. Gamma-proteobacteria that colonize the pancreatic tumors contribute to chemoresistance against gemcitabine by metabolizing the drug to a less active and deaminated form. The gemcitabine transporters of these bacteria are unknown to date.
View Article and Find Full Text PDFThe relation of sequence with specificity in membrane transporters is challenging to explore. Most relevant studies until now rely on comparisons of present-day homologs. In this work, we study a set of closely related transporters by employing an evolutionary, ancestral-reconstruction approach and reveal unexpected new specificity determinants.
View Article and Find Full Text PDFArticle Synopsis
- * Conducted with 261 healthcare workers at a COVID-19 hospital, it utilized anonymous questionnaires to assess their attitudes and behaviors towards patient care.
- * Results indicate that participants, primarily nurses, showed a strong intention to care for COVID-19 patients, with positive influences from social norms and prior experience in treating these patients.
Background: Studies on the serum concentration of hyaluronic acid (HA) in newly diagnosed patients with acute myeloid leukemia (AML), B-acute lymphoblastic leukemia (B-ALL), and mantle-cell lymphoma (MCL) are scarce. In this study, we focused on investigating whether HA could serve as a possible prognostic marker in patients with AML, B-ALL, and MCL.
Methods: The serum concentration of HA was measured in a total of 51 patients with newly diagnosed AML, B-ALL, and MCL.
Background: Hyaluronic acid (HA) has been found to be an important trigger of atherosclerosis. In this study, we investigate the possible association of serum HA with cardiovascular disease risk in a population of low/intermediate risk for cardiovascular events.
Methods: We enrolled 200 subjects with low/intermediate risk for developing cardiovascular disease.