Quantitative structure activity relationships (QSAR) of substituded (S)-phenylpiperidines as preferential dopamine autoreceptor antagonists.

A QSAR analysis for substituted (S)-phenylpiperidines as dopamine (DA) antagonists is described. The studied derivatives differ at the nitrogen substitutent (R) and at the substitutents (X) of the phenyl-ring. The analysis was done using the C-QSAR suite program (Biobyte) through the Internet.

Synthesis, antioxidant and antiinflammatory activity of novel aryla-cetic and aryl-hydroxamic acids.

Four new aryl-acetic acids and the corresponding hydroxamic acids were synthesized. These compounds showed interesting interaction with the free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH), scavenging activity on .OH, inhibition of soybean lipoxygenase and a significant inhibition of carrageenin induced paw edema in rats (44.