Impact of Minimally Manipulated Cell Therapy on Immune Responses in Radiation-Induced Skin Wound Healing.

The current treatment of radiation-induced skin wounds utilizes mainly conventional therapies, including topical steroids, creams, ointments, and hydrogel dressings, which do not take into account the immunologic changes that occur in the skin after radiation exposure. Therefore, it is relevant to consider alternative therapies and their impact on changes in the immune landscape of the skin. The aim of this study was to investigate the effect of allogeneic minimally manipulated keratinocytes and fibroblasts on rat skin repair and the development of immune responses.

Tumor-Associated Extracellular Matrix Obstacles for CAR-T Cell Therapy: Approaches to Overcoming.

Chimeric antigen receptor (CAR)-T cell therapy yields good results in the treatment of various hematologic malignancies. However, the efficacy of CAR-T cell therapy against solid tumors has proven to be limited, primarily because the tumor-associated extracellular matrix (ECM) creates an intractable barrier for the cytotoxic CAR-T cells that are supposed to kill cancer cells. This review unravels the multifaceted role of the tumor-associated ECM in impeding CAR-T cell infiltration, survival, and functions within solid tumors.

Effectiveness of Stem Cell Therapy for Diabetic Foot Ulcers: Cell Therapy Alone is Not Enough for Effective Management of Chronic Wounds.

We read with great interest the meta-analysis by Mudgal et al. (2024) regarding the effectiveness and safety assessment of stem cell therapy for diabetic foot ulcers. Indeed, The management of chronic wounds requires innovative approaches to avoid unsuccessful outcomes, and stromal cell therapies have emerged as a potential solution for soft tissue repair.

Cartilage Laser Engraving for Fast-Track Tissue Engineering of Auricular Grafts.

In this study, the optimal engraving parameters were determined through the analysis of scanning electron microscopy (SEM) data, as follows: a laser power density of 5.5 × 10 W/cm, an irradiation rate of 0.1 mm/s, a well radius of 60 μm, a distance between well centers of 200 μm, and a number of passes for each well of 20.

Biological Efficacy of Ionizing Radiation Sources on 3D Organotypic Tissue Slices Assessed by Fluorescence Microscopy.

Objective: Traditional cell-based radiobiological methods are inadequate for assessing the toxicity of ionizing radiation exposure in relation to the microstructure of the extracellular matrix. Organotypic tissue slices preserve the spatial organization observed , making the tissue easily accessible for visualization and staining. This study aims to explore the use of fluorescence microscopy of physiologically relevant 3D tissue cultures to assess the effects of ionizing radiation.

Study on the Curing and Foaming of Surfactant-Modified Geopolymer Gels Based on Ash and Slag Waste from Coal Combustion.

This study explores the influence of temperature-time conditions, surfactants, and varied waste compositions on the curing of geopolymer gels, a foam formation with the properties of porous geopolymers. Findings reveal that a 6 h curing period leads to a density of 435 kg/m and strength of 0.66 MPa, with notable improvements at 12 h.

The effects of mesenchymal stromal cells and platelet-rich plasma treatments on cutaneous wound healing: ignoring the possibility of adverse events and side effects could compromise study results.

Common medical events may be associated with decreased immunologic activity and dysregulation of functional epithelial and neuronal tissues caused by growth factors and vesicle secretion by stem and somatic cells. Systemic injection of MSCs has been shown to reduce the immune response mainly through paracrine mechanisms, but some points related to the possibility of adverse events and side effects should be clarified. Flow cytometry for at least 20 cell markers is crucial to assess cell senescence and overall cell viability.

Mechanism of Cs Immobilization within a Sodalite Framework: The Role of Alkaline Cations and the Si/Al Ratio.

Conditioning of radioactive waste generated from the operation of medical institutions, nuclear cycle facilities, and nuclear facilities is important for the safety of the environment. One of the most hazardous radionuclides is radioactive cesium. There is a need for more effective solutions to contain radionuclides, especially cesium (Cs+).

Influence of Various Coal Energy Wastes and Foaming Agents on Foamed Geopolymer Materials' Synthesis.

The regularities of obtaining foamed alkali-activated geopolymer materials based on different wastes of coal power engineering (fly ash, fuel (boiler) slag, ash, and slag mixture) were considered. The phase composition of the studied waste showed the presence of a significant amount of the amorphous phase, as well as a crystalline phase. mostly in the form of high quartz.

Role of Carbon Phase in the Formation of Foam Glass Porous Structure.

The production of durable, non-combustible, heat-insulating materials is currently very important. One of the most promising materials is foam glass. Modern enterprises widely use organic foaming agents in foam glass production.

Adverse events, side effects and complications in mesenchymal stromal cell-based therapies.

Numerous clinical studies have shown a wide clinical potential of mesenchymal stromal cells (MSCs) application. However, recent experience has accumulated numerous reports of adverse events and side effects associated with MSCs therapy. Furthermore, the strategies and methods of MSCs therapy did not change significantly in recent decades despite the clinical impact and awareness of potential complications.

Improving the Properties of Porous Geopolymers Based on TPP Ash and Slag Waste by Adjusting Their Chemical Composition.

The possibility of improving the properties of porous geopolymer materials based on ash and slag waste from thermal power plants by adjusting their chemical composition is considered. An X-ray phase analysis of ash and slag wastes was carried out, the geopolymers' precursor compositions were calculated, and additives to correct their chemical composition were selected. The samples were synthesized and their physical and mechanical properties (density, porosity, compressive strength, thermal conductivity) were analyzed.