Publications by authors named "Elena Y Taranukhina"
Acute alcohol administration is harmful especially for the developing nervous system, where it induces massive apoptotic neurodegeneration leading to alcohol-related disorders of newborn infants. Neuroprotection against ethanol-induced apoptosis may save neurons and reduce the consequences of maternal alcohol consumption. Previously we have shown that taurine protects immature cerebellar neurons in the internal granular layer of cerebellum from ethanol-induced apoptosis.
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- Acute ethanol exposure in developing mice causes significant neurodegeneration, specifically affecting Purkinje cells in the cerebellum during critical postnatal periods.
- Administration of taurine alongside ethanol reduced indicators of apoptosis in mice on postnatal day 7 (P7), but did not protect Purkinje cells on postnatal day 4 (P4).
- The effectiveness of taurine as a neuroprotective agent may depend on neuron type and requires consistent high levels in the blood for optimal results.
Acute ethanol administration causes extensive apoptosis throughout the nervous system. We studied the protective effect of taurine on alcohol-induced apoptosis in the cerebellum of developing mice. Taurine rescued a part of immature neurons by markedly reducing caspase-3 immunoreactivity and the number of TUNEL-positive cells in most cerebellar lobules.
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