Transplanted Murine Tumours SPECT Imaging with Tc Delivered with an Artificial Recombinant Protein.

Tc is a well-known radionuclide that is widely used and readily available for SPECT/CT (Single-Photon Emission Computed Tomography) diagnosis. However, commercial isotope carriers are not specific enough to tumours, rapidly clear from the bloodstream, and are not safe. To overcome these limitations, we suggest immunologically compatible recombinant proteins containing a combination of metal binding sites as Tc chelators and several different tumour-specific ligands for early detection of tumours.

CT and MRI Imaging of Theranostic Bimodal FeO@Au NanoParticles in Tumor Bearing Mice.

Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The FeO core was introduced into gold nanoparticles to form a core/shell structure suitable for MRI imaging.