Publications by authors named "Elena Wolodimeroff"
Background: Hemodynamic wall shear stress (WSS) exerted on the endothelium by flowing blood determines the spatial distribution of atherosclerotic lesions. Disturbed flow (DF) with a low WSS magnitude and reversing direction promotes atherosclerosis by regulating endothelial cell (EC) viability and function, whereas un-DF which is unidirectional and of high WSS magnitude is atheroprotective. Here, we study the role of EVA1A (eva-1 homolog A), a lysosome and endoplasmic reticulum-associated protein linked to autophagy and apoptosis, in WSS-regulated EC dysfunction.
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- - The study aimed to evaluate the relationship between cardiovascular medications and survival outcomes in patients showing symptoms of heart failure (HF), high NT-proBNP levels, but without confirmed HF on heart imaging.
- - Data was collected from 1,766 patients in the Sheffield HEArt Failure (SHEAF) registry, revealing that younger patients and those with conditions like hypertension or atrial fibrillation had better survival rates, while male gender and certain health issues increased mortality risk.
- - Although beta-blockers appeared to be associated with lower mortality when analyzed individually, this significance disappeared after adjusting for other factors, suggesting that no cardiovascular medications notably improved survival for these patients.