Publications by authors named "Elena Voropaeva"
Invasive pneumococcal disease remains one of the leading causes of morbidity and mortality worldwide. In Russia, 13- valent pneumococcal conjugate vaccine (PCV13) was introduced into the childhood immunization programme nationwide in 2014. As part of the Global Pneumococcal Sequencing Project (GPS), we used genome data to characterize 179 pneumococcal isolates collected from Russia in 2011-2018 to investigate the circulating pneumococcal strains using a standardized genomic definition of pneumococcal lineages (global pneumococcal sequence clusters, GPSCs), prevalent serotypes and antimicrobial resistance profiles.
View Article and Find Full Text PDFThe regulation of oncogenes by microRNA is a focus of medical research. hsa-miR-203, hsa-mir-129, hsa-miR-34a, hsa-miR-34b and hsa-miR-34c are oncosuppressive microRNAs that mediate the antitumor activity of p53. We seek to evaluate the frequencies, co-occurrence and clinical significance of the methylation of the , , and genes in the tumor tissue of diffuse large B-cell lymphoma (DLBCL).
View Article and Find Full Text PDFBackground: The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use. The network was established to strengthen surveillance and laboratory confirmation of meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis.
Methods: Sentinel hospitals report cases of children <5 years of age hospitalized for suspected meningitis.
Article Synopsis
- - The study focuses on the rare SNP rs78378222 in the 3'-UTR of a gene, which has been linked to increased cancer risk and may affect mRNA processing; it specifically looks into its prevalence and the loss of the protective A allele in patients with diffuse large B-cell lymphoma (DLBCL).
- - DNA was extracted from tumor and blood samples to genotype rs78378222 using PCR-RFLP and confirm with Sanger sequencing; results showed that 8.1% of DLBCL samples carried the SNP, with rare allele C found in 4.2% of cases, and heterozygosity loss was observed in some samples.
- - The findings suggest that the loss of the
Article Synopsis
- The study investigates how TP53 dysfunction occurs in diffuse large B-cell lymphoma by examining gene mutations, promoter methylation, and allelic imbalance.
- Researchers analyzed DNA from 74 patients and found that most mutations affected the TP53 gene's DNA-binding domain, with specific codons being mutation hotspots.
- The findings suggest a two-step process in tumor formation, where initial mutations or methylation increase cancer risk, followed by the loss of the normal TP53 allele, which is necessary for tumor development.
Article Synopsis
- The study investigates BRCA1 mutations related to hereditary breast cancer among the indigenous Buryat population, which are different from those common in the Slavic population of Russia.
- Researchers used Sanger sequencing to analyze blood samples and discovered 11 polymorphisms and 6 new unclassified sequence variants in the BRCA1 gene.
- The study highlights the need for further research to understand how these new variants might affect breast cancer risk in the Buryat Mongol population.
Frequencies of polymorphisms of genes BRCA1 and TP53 in breast cancer (BC) patients with a BC family history and radiation history were assessed and compared in the Semey region of Kazakhstan. The study included 60 women directly irradiated by the activities of the Semipalatinsk test site with a calculated effective equivalent dose of 500 mSv and their first generation descendants (group BC+Her+Exp); 65 women with family BC and absence of radiological history - the effective equivalent dose due to anthropogenic sources not exceeding 50 mSv (group BC+Her-Exp). The comparison group consisted of 65 women patients with breast cancer without family and radiological history (BC-Her-Exp).
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the link between the TP53 rs1625895 gene variation and the effectiveness of R-CHOP therapy in 106 patients diagnosed with diffuse large B cell lymphoma (DLBCL).
- Patients underwent six to eight cycles of R-CHOP treatment as their primary therapy, and the gene variant was analyzed using a specific genetic testing method.
- Results indicated that those with the G/G genotype of the TP53 rs1625895 polymorphism had a higher chance of R-CHOP treatment failing, with lower rates of remission and reduced overall and relapse-free survival after five years.
We investigated the role of single nucleotide polymorphisms (SNPs) in the folate-metabolizing genes MTHFR, MTR, MTRR, MTHFD, CBS and SHMT in regulating genetic susceptibility to Non-Hodgkin's lymphoma (NHL). We determined the allele and genotype frequencies in the case group (146 patients with NHL) and the control group (540 blood donors). A significant association with NHL was observed only for MTHFD1 G1958A (allele G OR=1.
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