Publications by authors named "Elena Verrengia"
Background: Cryptogenic organizing pneumonia (COP) is an interstitial lung disease, with causes including anti-CD20 antibodies. Ocrelizumab is a humanized monoclonal antibody against CD20 approved for use in relapsing-remitting or primary progressive multiple sclerosis (MS), with no conclusive data regarding pulmonary toxicity.
Cases: We describe two cases of COP associated with ocrelizumab use in multiple sclerosis patients.
Article Synopsis
- Maternal COVID-19 is linked to worse outcomes for mothers, but its effects on pregnant women with multiple sclerosis (MS) had not been thoroughly examined prior to this study.
- This multicenter study focused on pregnant women with MS who contracted COVID-19, assessing their maternal and fetal health outcomes compared to a control group.
- Findings revealed that while COVID-19 increased the risk of maternal complications, it did not significantly affect rates of spontaneous abortion or fetal malformations.
Article Synopsis
- - The study aimed to investigate the effects of long-term exposure to air pollutants (PM2.5, PM10, and NO2) on the severity of Covid-19 pneumonia specifically in patients with Multiple Sclerosis (MS), building on previous research that only considered PM2.5.
- - Researchers conducted a case-control study with 491 MS patients, utilizing statistical methods such as logistic regression and weighted quantile sum regression to analyze the relationship between pollutant exposure and the likelihood of developing Covid-19 pneumonia.
- - Results indicated that higher levels of PM2.5, PM10, and NO2 were significantly linked to increased chances of Covid-19 pneumonia, with NO2 and PM2.5 identified as the most
Objective: To investigate both muscular manifestations and CK levels in a large cohort of patients with COVID-19 infection and to determine whether hyperckemia is associated with morbidity and mortality.
Methods: Data of 615 patients discharged from ASST Ovest Milanese (Milan, Lombardy, Italy) with final diagnosis of COVID-19 infection were retrospectively extracted from electronical medical records from 21 February to 1 May 2020. Patients were descriptively analyzed with respect to the following variables: sex, age, muscular manifestations (myalgia and/or arthralgia), fatigue, respiratory involvement (SARS pneumonia or respiratory failure) and history of falls.
We describe the case of a 79-year-old woman infected by SARS-CoV-2 and purely neurological confusional syndrome without clinically relevant respiratory disease and NMR alterations of the limbic system.
View Article and Find Full Text PDFFrequency of diabetes and other comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy and their impact on clinical presentation and response to therapy.
J Neurol Neurosurg Psychiatry
October 2020
Article Synopsis
- A study was conducted to examine the prevalence of comorbidities in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and how these comorbidities impact treatment and outcomes.
- Of the 393 CIDP patients surveyed, 75% reported having at least one comorbidity, which affected treatment choices for nearly 49% of them, particularly reducing the use of corticosteroids.
- Notably, diabetes, monoclonal gammopathy of undetermined significance (MGUS), and other immune disorders were found to be more common in CIDP patients compared to the general population, with diabetes negatively influencing disability and treatment response.
Article Synopsis
- - This study investigates ischemic cerebrovascular events in patients with nonvalvular atrial fibrillation (AF) who are being treated with non-vitamin K antagonist oral anticoagulants (NOACs) to identify risk factors and understand the underlying mechanisms.
- - The research involved 713 patients who experienced ischemic strokes or transient ischemic attacks while on NOACs, and 700 who did not, revealing significant associations between these events and factors like low NOAC dosage, atrial enlargement, hyperlipidemia, and higher CHADS-VASc scores, which indicate greater stroke risk.
- - Findings suggest that while most strokes in this population were of cardioembolic origin, other factors such as being older,
Background And Purpose: Lombardia GENS is a multicentre prospective study aimed at diagnosing 5 single-gene disorders associated with stroke (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Fabry disease, MELAS [mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes], hereditary cerebral amyloid angiopathy, and Marfan syndrome) by applying diagnostic algorithms specific for each clinically suspected disease
Methods: We enrolled a consecutive series of patients with ischemic or hemorrhagic stroke or transient ischemic attack admitted in stroke units in the Lombardia region participating in the project. Patients were defined as probable when presenting with stroke or transient ischemic attack of unknown etiopathogenic causes, or in the presence of <3 conventional vascular risk factors or young age at onset, or positive familial history or of specific clinical features. Patients fulfilling diagnostic algorithms specific for each monogenic disease (suspected) were referred for genetic analysis.
Stroke is the leading cause of disability in adulthood, and the principal aim of care in cerebrovascular disease is the reduction of this negative outcome and mortality. Several studies demonstrated the efficacy of thrombolytic therapy in ischemic stroke, but up to 80% of cases could not be treated because the diagnostic workup exceeds the time limit. In this article, we described the design of a study conducted in the northern Lombardy, within the district of Sondrio, Lecco, Como, and Varese.
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