Magnetic resonance imaging of changes in the brain of children cured of acute lymphoblastic leukemia.

This study was aimed to systematize magnetic resonance imaging (MRI) presentation of toxic leukoencephalopathy, to find the correlation between method of central nervous system (CNS) leukemia prevention and changes on MRI, to find relationship between existence leukoencephalopathy on imaging and neurocognitive deficits in pediatric patients after anti-leukemic therapy. Brain MRI data of 48 children, who underwent a therapy course according to the ALL-MB intermediate risk protocol, was evaluated. In accordance with two arms of this protocol, they received either radiation therapy, or additional intrathecal administration of chemotherapeutic agents as a prevention of CNS leukemia.

Whole blood and hair trace elements and minerals in children living in metal-polluted area near copper smelter in Karabash, Chelyabinsk region, Russia.

The primary aim of the study is assessment of hair and whole blood trace element and mineral levels in children living in a polluted area near a copper smelter (Karabash) and two control locations (Varna, Tomino) using inductively coupled plasma mass spectrometry. The obtained data indicates that both blood and hair As, Pb, and Fe levels in children living in Karabash significantly exceeded the control values. Whole blood levels of copper in children living in Varna exceeded that in Tomino (p = 0.