Antibodies from the Sera of Multiple Sclerosis Patients Efficiently Hydrolyze Five Histones.

It is known that intranuclear histones can be pernicious after entering to the extracellular space. In addition, the immunization of animals with exogenous histones leads to systemic inflammatory and toxic reactions. Abzymes-autoantibodies with enzymatic activities-are the distinctive feature of autoimmune diseases and they can be especially dangerous to humans.