Publications by authors named "Elena V Karaduleva"
For the first time, based on the expression analysis of a wide range of pro- and anti-fibrotic, pro- and anti-inflammatory, and pro- and anti-apoptotic genes, key markers of endoplasmic reticulum stress (ER-stress), molecular mechanisms for the regulation of fibrosis, and accompanying negative processes caused by thioacetamide (TAA) injections and subsequent injections of selenium-containing nanoparticles and sorafenib have been proposed. We found that selenium nanoparticles of two types (doped with and without sorafenib) led to a significant decrease in almost all pro-fibrotic and pro-inflammatory genes. Sorafenib injections also reduced mRNA expression of pro-fibrotic and pro-inflammatory genes but less effectively than both types of nanoparticles.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on developing biodegradable polymer coatings for stents using poly(lactic-co-glycolic acid) (PLGA), which can release large molecules like prourokinase over time.
- The coatings exhibit significant elasticity and tensile strength, degrade slowly in isotonic solutions (0.05%-1.0% per day), and maintain around 90% enzymatic activity of prourokinase during release.
- Testing in animals showed no short-term toxicity or complications post-surgery, with minimal traces of PLGA found after 60 days, indicating the coatings are safe and effective for medical use.