Publications by authors named "Elena Trevisan"
Article Synopsis
- This study investigates the metabolic changes during the early stages of liver cancer (HCC) in a rat model, revealing that aggressive preneoplastic cells exhibit decreased oxidative phosphorylation and increased glucose use for the pentose phosphate pathway.
- The research identifies the roles of mitochondrial chaperone TRAP1 and transcription factor NRF2 in promoting these changes, showing that they are key indicators of aggressive liver lesions, as opposed to benign growth.
- Findings suggest that high levels of the pentose pathway enzyme G6PD in human HCC patients are linked to tumor severity and poor survival outcomes, highlighting the significance of these metabolic alterations in cancer progression.
Mitochondria of Drosophila melanogaster undergo Ca(2+)-induced Ca(2+) release through a putative channel (mCrC) that has several regulatory features of the permeability transition pore (PTP). The PTP is an inner membrane channel that forms from F-ATPase, possessing a conductance of 500 picosiemens (pS) in mammals and of 300 pS in yeast. In contrast to the PTP, the mCrC of Drosophila is not permeable to sucrose and appears to be selective for Ca(2+) and H(+).
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