Publications by authors named "Elena Tomeva"
To examine the butyrate- and beta-hydroxybutyrate (BHB)-modulated effects of pre- and probiotic interventions, fasting, and caloric restriction interventions, a systematic literature review was carried out with a subsequent meta-analysis. Three pre-and probiotic intervention randomized control trials (RCTs) were included in the meta-analysis. A significant increase in butyrate (standardized mean difference (SMD) [confidence interval (CI)] 0.
View Article and Find Full Text PDFThe importance of diet and lifestyle in maintaining overall health has long been recognised. MicroRNAs (miRNAs) have emerged as key players in the intricate interplay between health and disease. This study, including 305 participants, examined the role of miRNAs from capillary blood as indicators of individual physiological characteristics, diet, and lifestyle influences.
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- Dysregulation of epigenetic mechanisms, particularly related to miRNA expression, plays a significant role in cancer development, with noticeable differences between sexes.
- A study analyzed cell-free DNA methylation and miRNAs in plasma samples from healthy individuals and cancer patients, revealing several miRNAs that showed opposing expression patterns between males and females across various cancer types, including colorectal and stomach cancers.
- The findings underscore the importance of considering sex-specific differences in epigenetic regulation in cancer research, as the same miRNAs may have different impacts depending on the patient's sex and health status.
Article Synopsis
- Liquid biopsies are gaining importance for cancer diagnostics, focusing on developing tests that can simultaneously detect multiple types of solid tumors.
- Researchers analyzed cell-free DNA mutations, methylation, and circulating miRNAs from plasma samples of 97 cancer patients and 15 healthy controls to create a comprehensive test.
- A discriminant function model achieved high accuracy (95.4%), sensitivity (97.9%), and specificity (80%) in distinguishing between cancerous and healthy samples, highlighting the potential for improved cancer detection through combined genetic and epigenetic biomarker analysis.
Obesity- or diabetes-induced oxidative stress is discussed as a major risk factor for DNA damage. Vitamin E and many polyphenols exhibit antioxidative activities with consequences on epigenetic regulation of inflammation and DNA repair. The present study investigated the counteraction of oxidative stress by vitamin E in the colorectal cancer cell line Caco-2 under normal (1 g/l) and high (4.
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