: A Comprehensive Review of Its Therapeutic Potential, Pharmacological Properties, and Clinical Applications.

(NS) is an annual herb belonging to the Ranunculaceae family, also known as black cumin or black seed. This plant has been used since ancient times due to its therapeutic properties and has proven effective in gastrointestinal, respiratory, cardiovascular, infectious, and inflammatory conditions. In this review, the aim is to highlight the therapeutic effects of the plant known in Arab countries as "the plant that cures any disease", which are provided by the phytochemical compounds in its composition, such as thymoquinone, p-cymene, α-thujene, longifolene, β-pinene, α-pinene, and carvacrol.

MAPLE-prepared graphene oxide-based coatings for improved orthopedic screws used in knee interventions.

Orthopedic screws are subjected to high mechanical stress, corrosive environment, and microbial colonization, which may cumulatively lead to implant failure and periprosthetic joint infections. To overcome these issues, this study has focused on modifying the surface chemistry and topography of screws utilized in knee intervention toward enhancing their mechanical and biological behaviors. Specifically, this study has explored the optimization of composite coatings made of polycaprolactone (PCL), graphene oxide (GO), and Meropenem (MRP) via the matrix-assisted pulsed laser evaporation (MAPLE) technique.

Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview.

Since sarcopenia is a progressive condition that leads to decreased muscle mass and function, especially in elderly people, it is a public health problem that requires attention from researchers. This review aims to highlight drug delivery systems that have a high and efficient therapeutic potential for sarcopenia. Current as well as future research needs to consider the barriers encountered in the realization of delivery systems, such as the route of administration, the interaction of the systems with the aggressive environment of the human body, the efficient delivery and loading of the systems with therapeutic agents, and the targeted delivery of therapeutic agents into the muscle tissue without creating undesirable adverse effects.