Glucagon receptor signaling is not required for -carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice.

Glucagon regulates the hepatic amino acid metabolism and increases ureagenesis. Ureagenesis is activated by -acetylglutamate (NAG), formed via activation of -acetylglutamate synthase (NAGS). With the aim to identify the steps whereby glucagon both acutely and chronically regulates ureagenesis, we investigated whether glucagon receptor-mediated activation of ureagenesis is required in a situation where NAGS activity and/or NAG levels are sufficient to activate the first step of the urea cycle in vivo.

Glucagon Receptor Signaling and Glucagon Resistance.

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas). The suggested key role of glucagon in the development of diabetes has been termed the bihormonal hypothesis.

Developing lignin-based bio-nanofibers by centrifugal spinning technique.

Lignin-based nanofibers were produced via centrifugal spinning from lignin-thermoplastic polyurethane polymer blends. The most suitable process parameters were chosen by optimization of the rotational speed, nozzle diameter and spinneret-to-collector distance using different blend ratios of the two polymers at different total polymer concentrations. The basic characteristics of polymer solutions were enlightened by their viscosity and surface tension.