Publications by authors named "Elena Simona Bacaita"

This study describes the comparison between the interaction of a series of peptide-functionalized chitosan-based nanocapsules and liposomes with two cell lines, i.e., mouse macrophages RAW 264.

View Article and Find Full Text PDF

Nanotechnology is the science of creating materials at the nanoscale by using various devices, structures, and systems that are often inspired by nature. Micro- and nanoparticles (MPs, NPs) are examples of such materials that have unique properties and can be used as carriers for delivering drugs for different biomedical applications. Chitosan (CS) is a natural polysaccharide that has been widely studied, but it has a problem with low water solubility at neutral or basic pH, which limits its processability.

View Article and Find Full Text PDF

The present study analyzes (theoretically and experimentally) a drug release process from nanoparticles (polymeric nanocapsules and liposomes). This process is functionalized on the surface with an aptamer. These types of drug release processes can also be included in cream-type formulations.

View Article and Find Full Text PDF

New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water).

View Article and Find Full Text PDF

The aim of this study is to offer a comprehensive view on drug release from hydrogel, from both an experimental and a theoretical point of view. Aiming to benefit cyclodextrins' properties (not irritant; stable; able to modify the physical, chemical and biological properties of active compounds; accessible at low prices) and those of carrageenan polysaccharide (antitumor, immunomodulatory, antihyperlipidemic, anticoagulant, biocompatibility, biodegradability), original hydrogel films based on beta cyclodextrin and kappa carrageenan using epichlorohydrin as crosslinking agent were prepared and characterized from morphological and physical/chemical points of view. The results (morphology, the swelling degree, and the loading/release capacity) proved their potential as carriers for different types of drugs.

View Article and Find Full Text PDF