Publications by authors named "Elena Sendra"
Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the top emergent species associated with antimicrobial resistance that has become one of the greatest threat to public health in the twenty-first century. This bacterium is provided with a wide set of virulence factors that contribute to pathogenesis in acute and chronic infections. This review aims to summarize the impact of multidrug resistance on the virulence and fitness of P.
View Article and Find Full Text PDFPurpose: To design a randomized clinical trial to assess the efficacy and safety of favipiravir in patients with COVID-19 disease with pneumonia.
Methods: A randomized, double blind, placebo-controlled clinical trial of favipiravir in patients with COVID-19 pneumonia was conducted in three Spanish sites. Randomization 1:1 to favipiravir or placebo (in both groups added to the Standard of Care) was performed to treat the patients with COVID-19 pneumonia.
A retrospective case-control study to evaluate the use of beta-lactam desensitization in the management of penicillin-allergic patients: a potential strategy for Antimicrobial Stewardship Programs.
Front Pharmacol
November 2023
Article Synopsis
- There are a lot of people in hospitals who say they're allergic to penicillin, and this can make their treatment harder!
- A study compared patients who had a penicillin allergy and were treated with a special method called desensitization to those treated with other antibiotics!
- The results showed that even though the desensitized patients had more health problems, they didn't have worse outcomes than those who used alternative treatments, suggesting desensitization could be a helpful option!
The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the interest of researchers for decades because of its therapeutic implications, since it is classically assumed that resistance usually entails certain biological costs. Reviews on this topic revise the published data from a general point of view, including studies based on clinical strains or -evolved mutants in which the resistance phenotype is seen as a final outcome, i.e.
View Article and Find Full Text PDFTools for the evaluation of COVID-19 severity would help clinicians with triage decisions, especially the decision whether to admit to ICU. The aim of this study was to evaluate SeptiCyte RAPID, a host immune response assay (Immunexpress, Seattle USA) as a triaging tool for COVID-19 patients requiring hospitalization and potentially ICU care. SeptiCyte RAPID employs a host gene expression signature consisting of the ratio of expression levels of two immune related mRNAs, PLA2G7 and PLAC8, measured from whole blood samples.
View Article and Find Full Text PDFThe objective was to compare clinical characteristics, outcomes, and economic differences in complicated urinary tract infections (cUTI) caused by extensively drug-resistant Pseudomonas aeruginosa (XDR P. aeruginosa) and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-K. pneumoniae).
View Article and Find Full Text PDFAntibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review.
Expert Rev Anti Infect Ther
November 2022
Article Synopsis
- The study looked at how to help patients with allergies to antibiotics, which can make treatments less effective.
- Researchers tested a method called antibiotic desensitization and found it generally worked well and safely for these patients.
- In their review, they saw that almost all desensitization attempts were successful and no patients died from this procedure, suggesting it’s a good option for those allergic to penicillin.
A profile of delafloxacin in the treatment of adults with community-acquired bacterial pneumonia.
Expert Rev Clin Pharmacol
June 2022
Introduction: Community-acquired bacterial pneumonia (CABP) is the most common infectious cause of hospital admission in adults, and poses a significant clinical and economic burden. At the same time, antimicrobial resistance is increasing worldwide with only a few new antibiotics developed in recent years. Delafloxacin is an anionic fluoroquinolone available in intravenous and oral formulations and with a broad spectrum of activity targeting Gram-positives, including methicillin-resistant (MRSA), gram-negative organisms, and atypical and anaerobic organisms.
View Article and Find Full Text PDFComparison of Hospitalized Coronavirus Disease 2019 and Influenza Patients Requiring Supplemental Oxygen in a Cohort Study: Clinical Impact and Resource Consumption.
Clin Infect Dis
December 2022
Article Synopsis
- A study compared clinical characteristics and outcomes of patients with COVID-19 and seasonal influenza who needed supplemental oxygen, focusing on factors like age, comorbidities, and mortality rates.
- COVID-19 patients were generally younger but had more severe symptoms, including higher pneumonia rates and worse progression, leading to a significantly higher 30-day mortality rate of 15% compared to 5% for influenza patients.
- Additionally, COVID-19 patients experienced longer hospital stays and higher costs related to critical care and treatments compared to those with seasonal influenza.
Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study.
Infect Dis Ther
February 2022
Introduction: Extensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) infections are difficult to treat. We aimed to compare aminoglycosides or polymyxin monotherapy versus other antibiotic regimens (carbapenems, aztreonam, ceftazidime, cefepime, ceftolozane-tazobactam, or ceftazidime-avibactam) in complicated urinary tract infections (cUTI) caused by XDR-PA.
Methods: Study performed at a tertiary-care hospital from 2010 to 2019.
Risk Factors for Amoxicillin-Clavulanate Resistance in Community-Onset Urinary Tract Infections Caused by or : The Role of Prior Exposure to Fluoroquinolones.
Antibiotics (Basel)
May 2021
Background: High rates of amoxicillin-clavulanate (AMC) resistance among Enterobacterales isolated from urinary tract infections (UTIs) were observed in our area. The aim of this study was to identify risk factors associated with AMC resistance in patients with community-onset UTI in emergency departments (EDs).
Methods: A retrospective study was performed of all ED patients with positive urine cultures for or in a Spanish tertiary-care hospital.