Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents.

Using sclareol and sclareolide as starting materials, the guanidine derivatives of 12-amino-11-dihomodrimane-8α-ol and 13-amino-14,15-bis-dinorlabd-8(9)-ene were synthesized by the reaction of the corresponding amines with sodium hydrogencyanamide in ethanol - water solution. Monoacyl- and diacylguanidines were prepared from activated with N,N-carbonyldiimidazole Δ-bicyclohomofarnesenoic acid by the reaction with guanidine. Their structures were confirmed by the H and C NMR, IR spectral and elemental analysis data.