Validation of the electronic prescription as a method for measuring treatment adherence in hypertension.

Objective: To validate electronic prescriptions (e-prescriptions) as a method for measuring treatment adherence in patients with hypertension.

Methods: This prospective study initially included 120 patients treated for hypertension in primary care centers. Adherence was measured using the gold standard, the medication event monitoring system (MEMS), versus the index test, the e-prescription program, at baseline and at 6, 12, 18 and 24 months.

Improved evaporative light scattering detection for carbohydrate analysis.

Optimization and validation of evaporative light scattering detector (ELSD), aided by response surface methodology (RSM), has been developed for the liquid chromatography analysis of a wide molecular weight (MW) range of carbohydrates, including polysaccharides and oligosaccharides. Optimal experimental parameters for the ELSD detection were: 88.8°C evaporator temperature, 77.