Publications by authors named "Elena Morte-Romea"
Immunotherapy treatments aim to modulate the host's immune response to either mitigate it in inflammatory/autoimmune disease or enhance it against infection or cancer. Among different immunotherapies reaching clinical application during the last years, chimeric antigen receptor (CAR) immunotherapy has emerged as an effective treatment for cancer where different CAR T cells have already been approved. Yet their use against infectious diseases is an area still relatively poorly explored, albeit with tremendous potential for research and clinical application.
View Article and Find Full Text PDFAntibiotic use and outcome in patients with negative blood cultures, a new target population for antimicrobial stewardship interventions: A prospective multicentre cohort (NO-BACT).
J Infect
February 2024
Objectives: To evaluate the appropriateness of antimicrobial treatment and the risk factors for mortality in patients with negative blood cultures (BC), in order to evaluate whether this population would be a suitable target for antimicrobial stewardship (AMS) interventions.
Methods: A multicentre prospective cohort study of patients with negative BC in three Spanish hospitals between October 2018 and July 2019 was performed. The main endpoints were the appropriateness of antimicrobial treatment (evaluated by two investigators according to local guidelines) and 30-day mortality.
Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria.
Enferm Infecc Microbiol Clin (Engl Ed)
June 2023
Infections caused by multidrug resistant Gram-negative bacteria are becoming a worldwide problem due to their increasing incidence and associated high mortality. Carbapenem-resistant bacteria such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii are the most important in clinical practice. The objective of these guidelines is to update the recommendations for the diagnosis and treatment of infections caused by these multidrug resistant bacteria.
View Article and Find Full Text PDFA Large Multicenter Prospective Study of Community-Onset Healthcare Associated Bacteremic Urinary Tract Infections in the Era of Multidrug Resistance: Even Worse than Hospital Acquired Infections?
Infect Dis Ther
December 2021
Article Synopsis
- The study investigates healthcare-associated (HCA) bacteremic urinary tract infections (BUTI), comparing community-onset (CO-HCA) and hospital-acquired (HA) cases, particularly focusing on multidrug resistance (MDR) and outcomes.
- Conducted as a multicenter cohort study, it involved adult patients with specific inclusion and exclusion criteria, looking at factors like mortality and treatment appropriateness.
- Results showed a high prevalence of MDR (61.2%) among patients, with CO-HCA-BUTI patients generally older and sicker than those with HA-BUTI; however, mortality rates were not influenced by infection acquisition site or MDR presence.
Article Synopsis
- - Peritonitis can lead to sepsis, a severe inflammatory condition, and this study investigates the role of Granzyme A (GzmA), a protein produced by immune cells, in this process and its potential as a therapeutic target.
- - The research involved analyzing GzmA levels in patients with peritonitis and using mice models to study the effects of GzmA deficiency and inhibition on survival and inflammation during sepsis.
- - The results showed that higher GzmA levels are linked to worse outcomes in patients and that inhibiting GzmA in mice led to improved survival rates, suggesting GzmA contributes to inflammatory responses but does not affect bacterial control.
Sepsis is a serious global health problem. In addition to a high incidence, this syndrome has a high mortality and is responsible for huge health expenditure. The pathophysiology of sepsis is very complex and it is not well-understood yet.
View Article and Find Full Text PDFBackground: Detecting and managing antimicrobial drug interactions (ADIs) is one of the facets of prudent antimicrobial prescribing. Our aim is to compare the capability of several electronic drug-drug interaction (DDI) checkers to detect and report ADIs.
Methods: Six electronic DDI checking platforms were evaluated: Drugs.