Publications by authors named "Elena Morrone"
J Exp Clin Cancer Res
March 2024
Article Synopsis
- Targeting the interactions between tumor cells and their surrounding stroma presents a new approach for cancer therapy, potentially improving treatment efficacy against tumor growth, progression, and resistance to chemotherapy.
- Researchers developed gold-core/silica-shell nanoparticles embedded with an iridium(III) complex and decorated them with aptamers that target specific receptors (EGFR and PDGFRβ) on tumor and stromal cells, respectively.
- Results demonstrated that these dual-targeted nanoparticles entered and killed cancer cells more effectively than those targeting only one receptor, especially in complex stroma-rich tumor models, indicating a promising strategy in cancer treatment.
