α-tocopherol, a slow-binding inhibitor of acetylcholinesterase.

Acetylcholinesterase (AChE) is reversibly inhibited by α-tocopherol (α-T). Steady state kinetic analysis shows that α-T is a mixed slow-binding inhibitor of type A of human enzyme (K = 0.49 μM; K = 1.

H2O2 modifies membrane structure and activity of acetylcholinesterase.

The main factor of Alzheimer disease (AD) is beta-amyloid peptide (Abeta). It is known to affect acetylcholinesterase (AChE) through lipid peroxidation (LPO) initiated with H2O2 which is formed as a result of Abeta activity. The direct action of H2O2 on the enzyme is also possible.