Prevalence of hyperprolactinaemia in female premenopausal blood donors.

Objective: The prevalence of asymptomatic hyperprolactinaemia has been widely studied in certain populations such as antipsychotic drugs users, infertile women or patients with primary hypothyroidism, but data on the prevalence of hyperprolactinaemia and macroprolactinaemia in the healthy population are very scarce in the literature. We aimed to obtain an unbiased estimation of the prevalence in premenopausal women of: (i) hyperprolactinaemia and (ii) its aetiology, including macroprolactinaemia and stress-related hyperprolactinaemia, while considering simultaneously the use of hormonal contraceptives.

Design: Prevalence survey.

Dyspnea and stridor due to multinodular goiter in an obese woman.

Substernal multinodular goiter is a common entity that may cause life threatening pressure symptoms. We report the case of a patient with tracheal stenosis due to multinodular goiter and discuss various treatment options.

Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome.

Context: Oral contraceptives may worsen the metabolic profile of patients with polycystic ovary syndrome (PCOS), favoring the use of insulin sensitizers in these patients.

Objective: The aim of the study was to compare the effects of a contraceptive pill on metabolic classic cardiovascular risk factors with those of the insulin sensitizer metformin.

Design: We conducted a randomized, parallel, open-label clinical trial.