Publications by authors named "Elena M Ramos"
The density and type of lymphocytes that infiltrate colon tumors are predictive of the clinical outcome of colon cancer. High densities of T helper 17 (T(H)17) cells and inflammation predict poor outcome, whereas infiltration by T regulatory cells (Tregs) that naturally suppress inflammation is associated with longer patient survival. However, the role of Tregs in cancer remains controversial.
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- HCN channels in neurons are regulated by their location within the cell, which is influenced by the auxiliary subunit TRIP8b.
- In adult mice lacking TRIP8b, there’s an increase in axonal HCN1 channels, while mice with specific TRIP8b mutations show HCN1 distribution similar to normal mice.
- TRIP8b isoforms, especially TRIP8b(1a), play a key role in directing HCN1 channels within neurons, with age changes in TRIP8b levels affecting how and where HCN channels are expressed.