Publications by authors named "Elena Lindemann-Perez"
Article Synopsis
- Current methods for studying microbial gene expression in infected tissues are limited to bulk analyses, which overlook the diversity of individual cells and the tissue's structure.
- This study introduces a new technique, HCR RNA-FISH, that allows visualization and quantification of gene transcripts at a single-cell level in the infected tongues of mice.
- By using this method, researchers observed significant variations between cells and unique patterns of mRNA expression related to oral candidiasis, enhancing our understanding of how fungal pathogens interact with host tissues.
Candida albicans is a ubiquitous fungus of humans. It is not only a component of the oral and intestinal microbiota of most healthy adults but also a major cause of mucosal disorders and life-threatening disseminated infections. Until recently, research on the biology and pathogenesis of the fungus was largely based on a single clinical isolate.
View Article and Find Full Text PDFAdhesion to mucosal surfaces is a critical step in many bacterial and fungal infections. Here, using a mouse model of oral infection by the human fungal pathobiont Candida albicans, we report the identification of a novel regulator of C. albicans adhesion to the oral mucosa.
View Article and Find Full Text PDFThe signals that denote mammalian host environments and dictate the activation of signaling pathways in human-associated microorganisms are often unknown. The transcription regulator Rtg1/3 in the human fungal pathogen Candida albicans is a crucial determinant of host colonization and pathogenicity. Rtg1/3's activity is controlled, in part, by shuttling the regulator between the cytoplasm and nucleus of the fungus.
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