Klotho Gene and Protein in Human Placentas According to Birth Weight and Gestational Age.

Fetal growth restriction may be the consequence of maternal, fetal, or placental factors. The insulin-like growth factors (IGFs) are major determinants of fetal growth, and are expressed in the mother, fetus and placenta in most species. Previously we reported higher placental protein content of IGF-I, IGF-IR, and AKT in small (SGA) compared with those from appropriate for gestational age (AGA) placentas.

[A new fetal death classification system].

Background: Stillbirth is the mayor contributor to perinatal mortality.

Aim: To report a system for classification of fetal deaths.

Material And Methods: Retrospective cohort study of 29,916 births with 258 fetal deaths that occurred in a public hospital.

[Obesity, a risk factor for ascending bacterial infection during pregnancy].

Background: Obesity in pregnancy is associated with significantly higher rates of infection.

Aim: To compare the infectious morbidity in pregnant women with normal and altered body mass index (BMI).

Material And Methods: Cross sectional retrospective study of 6,150 patients who had delivery or second trimester abortion during 2012.

IGF-IR signal transduction protein content and its activation by IGF-I in human placentas: relationship with gestational age and birth weight.

Introduction: The human placenta expresses the IGF-I and IGF-IR proteins and their intracellular signal components (IRS-1, AKT and mTOR). The aim of this study was to assess the IGF-IR content and activation of downstream signaling molecules in placentas from newborns who were classified by gestational age and birth weight. We studied placentas from 25 term appropriate (T-AGA), 26 term small (T-SGA), 22 preterm AGA (PT-AGA), and 20 preterm SGA (PT-SGA) newborns.

[Risk factors for preterm deliveries in a public hospital].

Background: Preterm births are responsible for 75 to 80% of perinatal mortality.

Aim: To determine the factors associated with preterm births, using maternal clinical data, laboratory results and pathological placental findings.

Patients And Methods: Retrospective study of 642 preterm single births at 22-34 weeks' gestation.

Acid-labile subunit (ALS) gene expression and protein content in human placentas: differences according to birth weight.

Context: In humans, IGF-I and -II have an important role in pre- and postnatal growth. The IGFs circulate in plasma principally as a ternary complex with the IGF binding protein-3 and an acid-labile subunit (ALS), which increases their half life.

Objectives: The objectives of the study were to determine whether the human placenta expresses the mRNA and protein for ALS and to evaluate any possible differences in the mRNA and protein for ALS in placentas from small (SGA) and appropriate (AGA) or gestational age newborns.

[Fatal neonatal sepsis caused by vertical transmission of Morganella morganii. Report of one case].

We report a term neonate who developed early-onset sepsis due to Morganella morganii. The child was vaginally delivered after a short labor, and presented signs of perinatal asphyxia. Blood cultures taken soon after birth and from mother's lochia were positive for this microorganism.

[Relationship between periodontal diseases and ascending bacterial infection with preterm delivery].

Background: There is an association between periodontal diseases and preterm delivery.

Aim: To assess the relationship between periodontal diseases, ascending bacterial infection and placental pathology with preterm delivery.

Patients And Methods: A periodontal examination and collection of amniotic fluid and subgingival plaque samples were performed in women with preterm labor with intact membranes, without an evident clinical cause or preterm premature rupture of membranes, without clinical chorioamnionitis or labor and a gestational age between 24 and 34 weeks.