Publications by authors named "Elena Husanu"
The polymorphism of oxyresveratrol, a natural extract widely used in traditional Asian medicine, was investigated by means of the most recent structure characterization techniques. A previously unknown anhydrate oxyresveratrol crystal structure was identified for the first time from a submicrometric polyphasic mixture using 3D electron diffraction (3D ED). Additionally, a new polymorph of the dihydrate form of oxyresveratrol was also discovered and structurally studied.
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- The antipsychotic drug olanzapine exhibits complex polymorphism, with one of its forms, form III, remaining structurally unknown for over 20 years due to its consistent presence alongside other forms and difficulty in isolation.
- The advance of 3D electron diffraction (3D ED) technology has made it possible to determine and refine the structure of olanzapine form III, highlighting the technique's effectiveness in analyzing complicated mixtures of small crystals.
- The newly determined structure of form III is monoclinic and shows a unique packing arrangement compared to form II, differing significantly from predictions made by energy-minimization algorithms.
In this study, the efficacy of two of the best performing green solvents for the fractionation of lignocellulosic biomass, cholinium arginate (ChArg) as biobased ionic liquid (Bio-IL) and ChCl:lactic acid (ChCl:LA, 1:10) as natural deep eutectic solvent (NADES), was investigated and compared in the pretreatment of an agri-food industry waste, apple fibers (90°C for 1 h). For the sake of comparison, 1-butyl-3-methylimidazolium acetate (BMIM OAc) as one of the best IL able to dissolve cellulose was also used. After the pretreatment, two fractions were obtained in each case.
View Article and Find Full Text PDFThe objective of this study was to examine the bioactivity of extracts from apple pomace obtained by non-conventional green extraction methods (DES systems). Bioactivity was antioxidant capacity and ability to stimulate insulin secretion from pancreatic beta-cells. The antioxidant capacity of extracts was examined using the DPPH and the FRAP assay.
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- Researchers developed improved inhibitors for MMP-12, which could help treat lung and heart diseases, by adding an ionic liquid structure to increase their water solubility.
- Four new biologically active salts were created by connecting a sulfonamide part of the MMP-12 inhibitor to different ionic liquids, showing promising activity and solubility.
- One of the new salts, based on imidazolium, was used to create gold nanoparticles that can target MMP-12, allowing for advanced studies on its location within cells using electron microscopy.
The crystal structure of GaP nanowires grown by Au-assisted chemical beam epitaxy was investigated as a function of group V flux and growth temperature. By increasing the tertiarybutyl phosphine flux we obtained nanowires with a stacking defect-free wurtzite crystal structure. Variation of growth temperature also had a profound impact on the crystal structure.
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