Role of Toll-Like Receptor 2 in Regulation of T-Helper Immune Response in Chronic Obstructive Pulmonary Disease.

Objective: According to modern views, the differences in the clinical course of chronic obstructive pulmonary disease (COPD) are associated with certain types of T-helper (Th) immune response. Recent data have shown that toll-like receptor 2 (TLR2) is involved in the development of Th immune response. However, TLR2-mediated regulation of Th subpopulation balance in COPD needs to be elucidated.

The response ranges of pulmonary function and the impact criteria of weather and industrial influence on patients with asthma living in Vladivostok.

Purpose: To determine the response of pulmonary function (PF) to the influence of environmental factors in patients with different levels of asthma control.

Materials And Methods: Patients with controlled (136 people) and uncontrolled (96 people) asthma living in the conditions of monsoon climate and technogenic pollution in Vladivostok were examined. Discriminant analysis that provides the basis for dividing initial data into classes, as according to standards and expert estimates, was used to calculate ranges of PF response in asthma patients.

The influence of weather and climate on patients with respiratory diseases in Vladivostok as a global health implication.

Purpose: To identify the formation of meteopathic reactions in patients with respiratory diseases under the influence of extreme weather changes in Vladivostok.

Methods: The short-term meteopathic reaction in patients with respiratory diseases to the impact of "Weather Complex", consisting of nine weather parameters, on the day of patient's examination and on 1 and 2 days before the examination, was assessed. 146 acclimatized residents of Vladivostok (29 patients with chronic bronchitis, 51 patients with controlled asthma, 39 patients with uncontrolled asthma and 27 healthy volunteers) were examined.

Impact evaluation of environmental factors on respiratory function of asthma patients living in urban territory.

Background: Environmental pollution, local climatic conditions and their association with the prevalence and exacerbation of asthma are topics of intense current medical investigation.

Materials And Methods: Air pollution in the area of Vladivostock was estimated both by the index of emission volumes of "air gaseous components" (nitrogen oxide and nitrogen dioxide, formaldehyde, hydrogen sulfide, carbon monoxide) in urban atmosphere and by mass spectrometric analysis of precipitates in snow samples. A total of 172 local asthma patients (101 controlled-asthma patients-CAP and 71 non-controlled asthma patients - nCAP) were evaluated with the use of spirometry and body plethysmography.