Publications by authors named "Elena Drousioti"
Germline commitment following primordial germ cell (PGC) specification during early human development establishes an epigenetic programme and competence for gametogenesis. Here we follow the progression of nascent PGC-like cells derived from human embryonic stem cells in vitro. We show that switching from BMP signalling for PGC specification to Activin A and retinoic acid resulted in DMRT1 and CDH5 expression, the indicators of migratory PGCs in vivo.
View Article and Find Full Text PDFArticle Synopsis
- In cancer immunotherapy, it's crucial for agents targeting immune responses to be specifically expressed on cancer cells and to provoke a strong immune reaction.
- Cancer Testis Antigens, normally found in the germ-line, are mistakenly expressed in various cancers and could be targeted for immune therapy due to this aberration.
- The study demonstrates the creation of an mCherry reporter cell line in HCT116 colorectal cancer cells, intended to help identify new regulators of CTA expression, potentially enhancing the effectiveness of cancer immunotherapy.