Publications by authors named "Elena Di Nino"
Objectives: CD248 is a glycoprotein, highly expressed on pericytes and fibroblasts (FBs), that is implicated in the fibrotic process. During angiogenesis, CD248 can promote vessel regression, binding multimerin-2 (MMRN-2). Thus, we investigated the expression of MMRN-2 in systemic sclerosis (SSc)-skin and of CD248 in isolated SSc-FBs.
View Article and Find Full Text PDFDuring rheumatoid arthritis (RA), the pathogenic role of resident cells within the synovial membrane is suggested, especially for a population frequently referred to as fibroblast-like synoviocytes (FLSs). In this study, we assess the markers of myofibroblast differentiation of RA-FLSs by ex vivo observations and in vitro evaluations following the stimulation with both TGF-β and IL-6. Furthermore, we investigated the possible inhibiting role of tofacitinib, a JAK inhibitor, in this context.
View Article and Find Full Text PDFTo assess stimulator of interferon genes (STING) pathway in patients with adult-onset Still's disease (AOSD) who were complicated or not by macrophage activation syndrome (MAS), evaluating peripheral blood mononuclear cells (PBMCs), and synovial tissues. The relative mRNA expression of key molecules of the STING pathway (i.e.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to deeply analyze macrophage activation syndrome (MAS) in adults with Still's disease by looking at cytokines, inflammation markers, and how multiple organs are affected.
- Researchers collected clinical data and used advanced techniques like Luminex multiplexing and mass cytometry to examine immune cells in AOSD patients, comparing those with and without MAS.
- Results revealed that elevated levels of specific cytokines, along with a distinct immune cell profile, could help differentiate MAS cases, indicating a significant role for IFN-γ and other factors in the inflammatory response associated with the disease.