Metamizol (dipyrone, optalgin) in pregnancy, is it safe? A prospective comparative study.

Aim: To assess the teratogenic effect of metamizol when used during the first trimester of pregnancy.

Methods: One hundred and eight women who used metamizol during the first trimester of pregnancy were recruited from 4 teratogen information centers in Israel (3) and in Italy (1). The study group was paired for age, smoking habits and alcohol consumption with a comparative group exposed to acetaminophen.