Publications by authors named "Elena Christ"
Article Synopsis
- Malaria parasites adapt by digesting host hemoglobin to obtain essential amino acids, leading to a connection between nutrient availability and how genes are expressed.
- The study finds that certain tRNAs, which help decode amino acids that are not provided enough by hemoglobin, are underexpressed, creating a mismatch for optimal translation.
- Proliferation-related genes that rely heavily on these tRNAs can have their protein synthesis regulated during times of nutrient stress, showcasing how metabolic adaptation influences protein evolution in these parasites.
The Plasmodium falciparum life cycle includes obligate transition between a human and mosquito host. Gametocytes are responsible for transmission from the human to the mosquito vector where gamete fusion followed by meiosis occurs. To elucidate how male and female gametocytes differentiate in the absence of sex chromosomes, we perform FACS-based cell enrichment of a P.
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