Publications by authors named "Elena Carrasco P"
Background: Pollution and viral infections could be associated with the incidence of type 1 diabetes mellitus.
Aim: To look for associations between the temporal patterns of Type 1 Diabetes Mellitus (T1D) in infants younger than the age of 15 years, and environmental factors, such as air pollution and viruses.
Material And Methods: Data registries from hospitals, emergency services, and the Infantile Diabetes Foundation were reviewed, corresponding to children aged less than 15 years, who received their first insulin injection between 2000 and 2007.
Article Synopsis
- Type 1 diabetes mellitus (T1D) leads to the destruction of pancreatic β cells and is linked to reduced expression of certain apoptosis markers in blood cells.
- A study found that T1D patients showed a significant decrease in pro-apoptotic genes fas and bax when exposed to high glucose levels, indicating altered apoptotic mechanisms.
- The findings suggest that high glucose conditions affect apoptosis pathways in T1D patients, with a notable increase in the anti-apoptotic gene xiap under these conditions.
Background: Growth Hormone Receptor (GRH) is expressed in the liver, pancreas, stomach and small intestine. A high expression of GHR mRNA in the mucosal gut suggests a possible role of this receptor on digestive and immune functions.
Aim: To investigate the putative effects of the GHRd3 variants on the cytokine profile and distribution of auto-antibodies in children with type 1 diabetes (T1D).
Background: Cytotoxic T lymphocyte associated antigen 4 (CTLA-4) has been one ofthe non HLA genes more commonly studied in type 1 diabetes mellitus (TID). CTLA-4 is a co-stimulation protein that has a key role in the negative regulation ofT cells and is related with a functional cytokine imbalance, generating a T helper (Th) 1 over Th2 dominance.
Aim: To analyze the association of +49 A/G polymorphism of CTLA-4 and its relationship with autoantibodies and cytokine expression in recently diagnosed TID patients.
Aim: To explore the contribution of the PD-1 gene polymorphisms involved in T1D as well as the relationship between the PD-1/CTLA-4 genes and soluble CTLA-4 concentrations.
Patients And Methods: 261 incident cases of T1D and 280 healthy children less 15 years old were included in this study. Haplotypes for polymorphisms of the PD-1 and CTLA-4 genes were determined by PCR and RFLP methods.