Publications by authors named "Elena Campos-Pardos"
Article Synopsis
- Human and animal tuberculosis is caused by the Mycobacterium tuberculosis Complex (MTBC), which has lost the ability to produce cobalamin (vitamin B12) but can still take it up from external sources.
- In experiments with mice, B12-deficient (anemic) animals showed improved survival and reduced bacterial presence in organs when infected with M. tuberculosis (Mtb), compared to non-anemic mice.
- The research suggests that low B12 levels interfere with Mtb's virulence, revealing a new host-pathogen interaction that could be significant for populations with vitamin B12 deficiencies.
Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in immunity and virulence have been largely explored, although its contribution to the safety and efficacy of live tuberculosis vaccines is less understood. In this study, we demonstrate that the synthesis of c-di-AMP is negatively regulated by the PhoPR virulence system.
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