Publications by authors named "Elena Barranco"

Article Synopsis
  • The methionine-valine polymorphic codon 129 of the prion protein gene (PRNP) is crucial in the development and expression of sporadic Creutzfeldt-Jakob disease (sCJD), influencing susceptibility and the types of prion strains that emerge.
  • Experiments using humanized transgenic mice isolated five prion strains which vary based on the conformations of the pathogenic prion proteins, with certain strains only found in specific codon 129 genotypes, including a new subtype identified in patients with the MV genotype.
  • A study identified six cases of sCJD in Catalonia and Italy showing unique clinical and neuropathological features that resemble the VV1 subtype, suggesting that these cases might
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Dementia in general--and Alzheimer's disease (AD) in particular--are bound to loom large among the most acute healthcare, social, and public health problems of the 21st century. AD shows a degenerative progression that can be slowed down--yet not halted--by today's most widely accepted specific treatments (those based on cholinesterase inhibitors as well as those using memantine). There is enough evidence to consider these treatments advisable for the mild, moderate and severe phases of the illness.

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Dementia is a syndrome characterized by a progressive deterioration of cognitive functions, accompanied by psychiatric symptoms and behavioral disturbances that produce a progressive and irreversible disability. The way it should communicate the diagnosis of dementia is a key discussion point on which there is no unanimous agreement so far. The communicating of the diagnosis of dementia is a complex issue that affects not only, the patient but also to caregivers and health professionals who care and must conform to the ethical principles governing medical practice (autonomy, nonmaleficence, beneficence, and justice).

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Background And Objectives: The management of psychological and behavioural symptoms associated with dementia frequently requires the use of neuroleptic drugs. The objective of this study was to determine the prevalence, characteristics and possible differential factors of people aged > or = 65 years with dementia who take or not neuroleptic drugs. The subgroup with Alzheimer disease was analysed.

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