Publications by authors named "Elena Bacigalupi"
Article Synopsis
- Acute coronary syndrome, cardiac surgery, and structural interventions frequently lead to the use of allogeneic red blood cells due to bleeding and anemia.
- The variability in blood transfusion use arises from limited data and a lack of clear guidelines, with an emphasis on avoiding unnecessary transfusions unless absolutely necessary.
- Future research needs to determine the role of blood transfusions in adverse events during cardiac interventions, and this review summarizes current literature and critiques the evidence surrounding their use.
Although the entire vascular bed is constantly exposed to the same risk factors, atherosclerosis manifests a distinct intra-individual pattern in localization and progression within the arterial vascular bed. Despite shared risk factors, the development of atherosclerotic plaques is influenced by physical principles, anatomic variations, metabolic functions, and genetic pathways. Biomechanical factors, particularly wall shear stress (WSS), play a crucial role in atherosclerosis and both low and high WSS are associated with plaque progression and heightened vulnerability.
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- - De-escalation of dual antiplatelet therapy (DAPT) is being explored to minimize bleeding risks while still protecting against heart-related issues, but doing so indiscriminately in high-risk patients may lead to serious heart events.
- - Emerging tools, like platelet function and genetic tests, could help tailor DAPT de-escalation, but they come with their own challenges and limitations.
- - High-risk patients, often excluded from clinical trials, lack specific guidelines, making the decision on how to adjust DAPT complex and needing personalized approaches.