Dabigatran Attenuates the Binding of Thrombin to Platelets-A Novel Mechanism of Action.

Background:  Thrombin is a multifunctional regulatory enzyme of the haemostasis and has both pro- and anticoagulant roles. It has, therefore, been a main target for drug discovery over many decades. Thrombin is a serine protease and possesses two positively charged regions called exosites, through which it is known to bind to many substrates.