Not always what closes best opens better: mesoporous nanoparticles capped with organic gates.

Four types of calcined MCM-41 silica nanoparticles, loaded with dyes and capped with different gating ensembles are prepared and characterized. and nanoparticles are loaded with rhodamine 6G and capped with bulky poly(ethylene glycol) derivatives bearing ester groups ( and ). nanoparticles are loaded with sulforhodamine B and capped with self-immolative derivatives bearing ester moieties.

Self-Immolative Linkers as Caps for the Design of Gated Silica Mesoporous Supports.

A new hybrid material based on sulforhodamine B dye-loaded silica mesoporous nanoparticles capped with a self-immolative gate has been synthesized and characterized. The gated material's controlled release behavior is monitored under different pH conditions. Under acidic and neutral conditions, a low level of dye release is detected.

Quantitative targeted biomarker assay for glycated haemoglobin by multidimensional LC using mass spectrometric detection.

The development of quantitative strategies for targeted biomarker analysis represents an urgent task especially in the field of clinical diagnosis. In this regard, the measurement of glycohaemoglobin (HbA(1c)) in blood has become the most specific way of monitoring long-term glycaemia in diabetic patients. Thus, there is an urgent need for methods that provide accurate and precise HbA(1c) results.