Publications by authors named "Elena Anna Boccalandro"

Article Synopsis
  • Doctors are now focusing on helping people with hemophilia keep their joints healthy and improve their quality of life instead of just stopping life-threatening bleeding.
  • Ultrasound is a helpful tool for quickly finding joint problems and can work with technology like artificial intelligence and telemedicine for better ongoing care.
  • Working with different types of doctors and therapists early on can help patients live a healthier and happier life.
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Emicizumab is approved for prophylaxis of patients with hemophilia A (HA). Despite its efficacy in reducing bleeding, some patients on emicizumab still experience hemarthrosis, but no tool is yet available to identify those at a higher risk of spontaneous joint bleeding. This study aimed to evaluate whether laboratory measurements (global coagulation assays and emicizumab concentration) and/or arthropathy scores can distinguish patients at higher risk of spontaneous joint bleeding while on emicizumab prophylaxis.

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Hemophilia is an inherited hemorrhagic disorder; its main clinical manifestations being bleeding in muscles and joints. Ankles, knees, and elbows are the most frequently affected joints, followed by shoulders and hips. The clinical signs of joint involvement are reduced mobility, swelling and walking difficulties.

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