Publications by authors named "Elena Akimenko"
Background And Aims: Selected patient groups with ulcerative colitis and Crohn's disease are at increased risk of colorectal cancer. Surveillance guidelines rarely cover patients after colectomy. We performed a nationwide population-based cohort study to estimate the risk of developing rectal cancer in patients with inflammatory bowel disease after subtotal colectomy.
View Article and Find Full Text PDFLow-dose azathioprine and allopurinol versus azathioprine monotherapy in patients with ulcerative colitis (AAUC): An investigator-initiated, open, multicenter, parallel-arm, randomised controlled trial.
Marianne Kiszka-Kanowitz Klaus Theede Sandra Bohn Thomsen Jacob Tveiten Bjerrum Jørn Brynskov Elena Akimenko
EClinicalMedicine
March 2022
Article Synopsis
- The study aims to compare the effectiveness of low-dose azathioprine combined with allopurinol to standard azathioprine alone in inducing remission in patients with moderate-to-severe ulcerative colitis.
- In this randomized trial involving 89 patients, those receiving the combination therapy had a significantly higher remission rate (43%) compared to those on monotherapy (21%) after one year.
- Although both treatment groups experienced adverse events, the combination therapy group showed promising results and potential benefits for patients struggling with ulcerative colitis.