Publications by authors named "Elena Acedo Reina"
Article Synopsis
- Seizures trigger both sympathetic and parasympathetic autonomic symptoms, with the vagus nerve playing a crucial role in relaying information between the brain and organs, potentially aiding in seizure detection.
- The study successfully developed a VENG detection algorithm that identified 65% of induced seizures in a rat model, demonstrating a mean detection delay of about 25 seconds but also highlighting that some seizures went undetected due to variability in detection parameters.
- Statistical analysis revealed differences in brain wave activity (Delta, Theta, Beta bands) between detected and undetected seizures, indicating distinct seizure patterns may influence how autonomic responses are activated; however, the lack of respiration data points to future research needs.
Potential intrinsic resistance mechanisms to regorafenib were explored after short exposure (3 days) on five CRC cell lines (HCT-116, SW1116, LS-1034, SW480, Caco-2). The observation of senescence-like features led to the investigation of a drug-initiated phenotype switch. Following long-term exposure (12 months) of HCT-116 and SW480 cell lines to regorafenib, we developed resistant models to explore acquired resistance.
View Article and Find Full Text PDFBackground: While circulating tumour (ct)DNA is an indicator of minimal residual disease and negative prognostic factor in stage II-III colon cancer, no study has ever analysed the value of this biomarker in colon cancer patients treated with neoadjuvant chemotherapy. We sought to fill this gap by using prospectively collected plasma samples from 80 stage III colon cancer patients, receiving one cycle of neoadjuvant FOLFOX followed by surgery +/- adjuvant FOLFOX in the PePiTA trial.
Material And Methods: Samples were collected at baseline, 2 weeks and surgery.
Background: Regorafenib is a standard treatment for refractory metastatic colorectal cancer (mCRC). In view of the toxicity burden, significant research efforts have been made to increase the therapeutic ratio of this multikinase inhibitor. Predictive factors for treatment-related adverse events (TRAEs), however, are still lacking.
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