Publications by authors named "Elena A Teplyashina"
Blood-brain barrier (BBB) is a structural and functional element of the neurovascular unit (NVU), which includes cells of neuronal, glial, and endothelial nature. The main functions of NVU include maintenance of the control of metabolism and chemical homeostasis in the brain tissue, ensuring adequate blood flow in active regions, regulation of neuroplasticity processes, which is realized through intercellular interactions under normal conditions, under stress, in neurodegeneration, neuroinfection, and neurodevelopmental diseases. Current versions of the BBB and NVU models, static and dynamic, have significantly expanded research capabilities, but a number of issues remain unresolved, in particular, personification of the models for a patient.
View Article and Find Full Text PDFArticle Synopsis
- * The NVU is made up of various brain cells that work together for communication, metabolism, and blood flow regulation, while the BBB controls what can enter and exit brain tissue, crucial for brain function and adaptability.
- * In Alzheimer’s disease, mitochondria are particularly affected by amyloid proteins, leading to NVU and BBB dysfunction, and this review explores how to study and potentially improve treatments using in vitro models of these structures.