Publications by authors named "Elena A Sebentsova"
Synthetic peptides have a wide range of clinical effects. Of particular interest are peptides based on adrenocorticotropic hormone (ACTH) both as already used and as potential drugs for preventing consequences of cerebral ischemia. However, it is necessary to study influence of the peptide on the brain cells under normal physiological conditions, including understanding the risks of their use.
View Article and Find Full Text PDFThe central effectors of the stress system are greatly interconnected and include, among others, a large group of peptides derived from proopiomelanocortin. In addition to natural corticotropins, a number of artificial molecules that contain some ACTH fragments in their structure are also referred to members of this family. Some of them possess a wide range of biological activity.
View Article and Find Full Text PDFArticle Synopsis
- Natural melanocortins (MCs), like Semax and ACTH(6-9)PGP, have shown potential in developing drugs with neuroprotective effects, particularly during stress.
- In an experiment with rats, both MC derivatives were found to reduce behavioral changes caused by acute restraint stress (ARS) when administered beforehand.
- RNA sequencing revealed that Semax affected over 1500 genes while ACTH(6-9)PGP affected fewer than 400, highlighting how these peptides help normalize gene expression disrupted by stress, particularly in the hippocampus.