Publications by authors named "Elena A Konnova"
Macrophages and satellite glial cells are found between injured and uninjured neurons in the lumbar dorsal root ganglia (DRG). We explored the mechanism of neuro-immune and neuron-glia crosstalk leading to hyperexcitability of DRG neurons. After spared nerve injury (SNI), CX3CR1 resident macrophages became activated, proliferated, and increased inward-rectifying potassium channel K 2.
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- Satellite glial cells (SGCs) in the dorsal root ganglion increase in number following nerve injury, contributing to neuropathic pain, with Glial Fibrillary Acidic Protein (GFAP) being a key activation marker.
- The study utilized hGFAP-CFP transgenic mice to analyze GFAP expression in the peripheral nervous system after a spared nerve injury, employing various research techniques.
- Findings revealed an increase in GFAP+ cells post-injury, with many being non-myelinating Schwann cells, indicating a complex role of GFAP in glial cell identification and response to nerve damage.